Major publications

• Matkarimov, B.T., Zharkov, D.O., and SAPARBAEV, M.K. (2019) Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage. Mutagenesis, Nov 29. pii: gez045. doi: 10.1093/mutage/gez045/5646155.

Mechanisms of DNA Repair and Carcinogenesis

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Lab members

Major Publications

• Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020, 130:1377-1391.
• Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nähse V, Jaszczyszyn Y, Lachages AM, Dutrillaux B, Thermes C, Debatisse M, Chen CL. Transcription-mediated organization of the replication initiation program across  large genes sets common fragile sites genome-wide. Nat Commun, 2019, 10:5693.

4Rs : Replication, Repair, Recombination and ROS

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Lab members

• Saïd AOUFOUCHI – Research Scientist – Group Leader
• Dorine BONTE – Assistant professeur -Paris Sud University
• Léticia KOCH- LERNER- Post doc
• Morwenna Le GUILLOU – Engineer assistant Paris Sud University
• Céline DECAUX- Master2 trainer programm UPMC
• Charlène TRILLeaud - Master1 trainer programm UPMC
• Roukia BELGADAR Undergraduate student –UPMC

Major publications since 2009

• Xavier Renaudin, Jean-Hugues Guervilly, Said Aoufouchi, and Filippo Rosselli.Proteome-wide analysis unveils a FANCA-modulated neddylation signaling pathway involved in CXCR5 membrane trafficking and cell mobility. 
• J Cell Sci. 2014 Aug 15;127(Pt 16):3546-54. doi: 10.1242/jcs.150706. Epub 2014 Jul 11.

Genome Plasticity and B cell

This group belongs to the group "TLS Polymerases: Genome Plasticity and Cancers" 

Our group associates researchers working on the coordination and regulation of DNA repair processes in B lymphocyte following AID expression and on the role of AID in B cell tumourigenesis. 

Lab members

• Patricia Kannouche (Directeur de recherche- CNRS), Manager
• Caroline Pouvelle (TCN CNRS)
• Emmanuelle Despras (Post-Doc GR)
• Sana Ahmed-Seguir (PhD student)
• Noémie Delrieu (PhD student, 4ème année ED Cancérologie, University Paris Sud)
• Yann Benureau (Engineer d’étude, GR- SIRIC)
• Mégane Bouvet (Technician, CDD-CNRS)
• Barbara Ben Yamin (Engineer assitant, CDD-CNRS)

Publications since 2008

• Sana Ahmed-Seghir, Caroline Pouvelle, Emmanuelle Despras, Agnès Cordonnier, Alain Sarasin and Patricia L Kannouche. Aberrant C-terminal Domain of Polymerase eta Targets the Functional Enzyme to the Proteosomal Degradation Pathway. DNA Repair, in revision.